Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum

Authors

  • Adel Sepanjnia Department of Biomedical Science, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
  • Akram Ranjbar Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  • Fatemeh Shabani Department of Biomedical Science, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
  • Fouzieh Salimi Department of Biomedical Science, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
  • Hassan Ghasemi Department of Clinical Biochemistry, Abadan Faculty of Medical Sciences, Abadan, Iran
  • Nejat Kheiripour Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  • Roohollah Mohseni Department of Biochemistry, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract:

Background: The present study aimed to evaluate the effects of different concentrations of cerium oxide nanoparticles (CONPs) on the oxidative stress (OS) status in kidney, lung, and serum of rats. Methods: Male Wistar Rats were treated intraperitoneally with 15, 30, and 60 mg/kg/day of CONPs. The biochemical parameters, including total antioxidant capacity (TAC), total thiol group (TTG), malondialdehyde (MDA), SOD (superoxide dismutase), and catalase (CAT) were assayed in serum, kidney, and lung tissues. Results: MDA decreased, but TTG and CAT increased in serum by the administration of CONPs at 15 mg/kg. In kidney homogenate obtained from the group treated with CONPs at 15 mg/kg, TAC, TTG, and CAT significantly increased compared to the control group. However, CONPs at 15, 30, and 60 mg/kg significantly decreased MDA level compared to the control group. In lung tissue, CONPs in doses of 15, 30 and 60 mg/kg significantly decreased CAT activity, TTG and TAC compared to the control group, while in kidney tissue, CONPs at the concentrations of 30 and 60 mg/kg significantly increased MDA compared to the control group. Conclusion: Our findings suggest that CONPs attenuate OS in the kidney and affect the serum levels of OS-related markers but induce OS in the lung tissue in a dose-dependent manner. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Experimental Study of Cerium Oxide Nanoparticles (CeNP) Against Malathion Induced Lung Oxidative Toxic Stress in Rats

Regardless of toxicity of nanoparticles, cerium oxide nanoparticles (CeNPs) are emerging as a multi-functional agent for biomedical purposes. On the other hand, Organophosphorus pesticides, like malathion, are inevitably found in the environment. The common involving pathway CeNPs and malathion share is oxidative stress. Therefore, we conducted this study to find the possible neutralizing or sy...

full text

Evaluation the effect of silver nanoparticles on oxidative stress biomarkers in blood serum and liver and kidney tissues

Objective(s): Silver nanoparticles (Ag-NPs) are one of the most widely used nanomaterials recently. Despite the wide application of nanomaterials, there is limited information concerning their impact on human health and the environment. This study aimed to find the effects of Ag-NPs (40 nm) on blood serum, liver and kidney tissues of homing pigeons (Columbia livia).Materials and Methods: Columb...

full text

Comparison the Effects of Cerium Nanoparticles (CeNP) and Cerium Oxide (CeO2) ‎‎on Oxidative Toxic Stress in Human Lymphocytes

Background: Dermatophytes are the most common fungal agents causing superficial skin infections in worldwide. Species identification of these fungi is important for therapeutic and epidemiological apects. The purpose of this study was to determine the epidemiology of dermatophytosis in patients referring to medical mycology laboratory of Razi hospital in Tehran, during 2014. Materials and Meth...

full text

the effect of oxytetracycline on serum calcium, phosphorus and magnesium in cattle

نتایج این مطالعه نشان می دهد که مقدار کلسیم (یونیزه و تام)، منیزیم و فسفر به طور معنی داری تغییر پیدا کرد به جزء مقدار کلسیم تام و منیزیم در روش داخل عضلانی که تغییر معنی داری نداشته است. بر اساس نتایج این مطالعه می توان نتیجه گیری کرد که اکسی تتراساکلین بر روی مقادیر سرمی کلسیم و منیزیم تأثیر می گذارد باید مقدار این کاتیون ها در بیماران، در هنگامی که اکسی تتراسایکلین استفاده می شود مورد توجه ق...

15 صفحه اول

evaluation the effect of silver nanoparticles on oxidative stress biomarkers in blood serum and liver and kidney tissues

objective(s): silver nanoparticles (ag-nps) are one of the most widely used nanomaterials recently. despite the wide application of nanomaterials, there is limited information concerning their impact on human health and the environment. this study aimed to find the effects of ag-nps (40 nm) on blood serum, liver and kidney tissues of homing pigeons (columbia livia).materials and methods: columb...

full text

Cerium oxide nanoparticles protect cardiac progenitor cells from oxidative stress.

Cardiac progenitor cells (CPCs) are a promising autologous source of cells for cardiac regenerative medicine. However, CPC culture in vitro requires the presence of microenvironmental conditions (a complex array of bioactive substance concentration, mechanostructural factors, and physicochemical factors) closely mimicking the natural cell surrounding in vivo, including the capability to uphold ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 24  issue 4

pages  251- 256

publication date 2020-07

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023